As Andy prepares to leave for college, his loyal toys find they have been donated to the Sunnyside Daycare where untamed tots with their sticky little fingers do not play nice. So, it's all for one and one for all as they join Barbie's counterpart Ken, a thespian hedgehog named Mr. Pricklepants, and a pink, strawberry-scented teddy bear called Lots-o'-Huggin' Bear to plan their great escape and ensure that no toy gets left behind.

The fun and adventure continues when Andy goes off to cowboy camp and the toys are left to their own devices. Things shift into high gear when an obsessive toy collector kidnaps Woody, who hasn't the slightest clue that he's a greatly valued collectible.

A boy's previously favorite toy develops an animosity toward the boy's brand new birthday toy.